I gave up on Clicker, at least for a little while. The trial ran out and I suspect it was making my machine unstable (at least Aqua). There are some reports on that and I started experiencing some weirdness after installing it. There's a new version out, but they want $10. I'll probably pick it up and try it out I'll let you know.
Konfabulator is also shareware and has an annoying window that reminds you to pay and can't be dismissed or reduced. I'm waiting to pay until I play around with changing some of the scripts and actually programming the thing. I think the folks at Vultus ought to check it out.