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Today I had to do a job interview with a candidate in Chile. He had Skype and wanted to use it. I was leery because I had four people on my end who needed to be in on the call, so USB headphones weren't going to cut it. We decided to press forward and try the call with the MBP's internal speakers and microphone.
It worked beautifully! We could hear him fine and he could hear us--even with some people sitting 8-10 feet from the laptop. So much so that this evening when I was getting ready to get on another call, I decided to Skype out to it rather than use my Polycom. Skype plus my Macbook Pro is the best conference phone I own.